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A Versatile Method for Preparing Polysaccharide Conjugates via Thiol-Michael Addition.
Chen J, Ma X, Edgar KJ. Chen J, et al. Polymers (Basel). 2021 Jun 8;13(12):1905. doi: 10.3390/polym13121905. Polymers (Basel). 2021. PMID: 34201140 Free PMC article.
The resulting polysaccharide, bearing alpha,beta-unsaturated esters with tunable DS (methacrylate), was reacted with various thiols, including 2-thioethylamine, cysteine, and thiol functional quaternary ammonium salt through thiol-Michael addition, affording functionalized …
The resulting polysaccharide, bearing alpha,beta-unsaturated esters with tunable DS (methacrylate), was reacted with various thiols, includi …
Intralysosomal hydrolysis of glycyl-L-phenylalanine 2-naphthylamide.
Jadot M, Colmant C, Wattiaux-De Coninck S, Wattiaux R. Jadot M, et al. Biochem J. 1984 May 1;219(3):965-70. doi: 10.1042/bj2190965. Biochem J. 1984. PMID: 6743255 Free PMC article.
The inhibition is markedly less pronounced when the free activity is determined; a high activity remains that depends on the integrity of the lysosomes; it decreases as the free activity of N-acetylglucosaminidase increases when lysosomes are subjected to treatments able to disru …
The inhibition is markedly less pronounced when the free activity is determined; a high activity remains that depends on the integrity of th …
Synthesis of guanosine and deoxyguanosine phosphoramidites with cross-linkable thioalkyl tethers for direct incorporation into RNA and DNA.
Hou X, Wang G, Gaffney BL, Jones RA. Hou X, et al. Nucleosides Nucleotides Nucleic Acids. 2009 Nov;28(11):1076-94. doi: 10.1080/15257770903368385. Nucleosides Nucleotides Nucleic Acids. 2009. PMID: 20183575 Free PMC article.
While the completed oligonucleotide is still attached to the support, or after purification, the tert-butyl thiol can readily be removed or replaced by thioethylamine or 5-thio-2-nitrobenzoic acid, which have more favorable crosslinking rates....
While the completed oligonucleotide is still attached to the support, or after purification, the tert-butyl thiol can readily be removed or …
Synthesis and biological evaluation of some 6-substituted purines.
Braga FG, Coimbra ES, de Oliveira Matos M, Lino Carmo AM, Cancio MD, da Silva AD. Braga FG, et al. Eur J Med Chem. 2007 Apr;42(4):530-7. doi: 10.1016/j.ejmech.2006.10.014. Epub 2006 Dec 6. Eur J Med Chem. 2007. PMID: 17156894
The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 [11,12] [corrected] 6-(3'-(thioethylamine)propylthio)purine 5, 6-(alpha-aceticacidthio)purine 7 and 6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine 14 with an IC( …
The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 [11,12] [corrected] 6-(3'-(th …
Characterisation and Evaluation of Trimesic Acid Derivatives as Disulphide Cross-Linked Polymers for Potential Colon Targeted Drug Delivery.
Mat Yusuf SNA, Ng YM, Ayub AD, Ngalim SH, Lim V. Mat Yusuf SNA, et al. Polymers (Basel). 2017 Jul 27;9(8):311. doi: 10.3390/polym9080311. Polymers (Basel). 2017. PMID: 30970988 Free PMC article.
The monomer was synthesised by an amide coupling reaction between trimesic acid and (triphenylmethyl) thioethylamine using a two-step synthesis method. The s-trityl group was removed using a cocktail of trifluoroacetic acid and triethylsilane to expose the thiols in prepar …
The monomer was synthesised by an amide coupling reaction between trimesic acid and (triphenylmethyl) thioethylamine using a two-step …
Colon targeted drug delivery of branch-chained disulphide cross-linked polymers: design, synthesis, and characterisation studies.
Lau Y, Lim V. Lau Y, et al. Chem Cent J. 2016 Nov 29;10:77. doi: 10.1186/s13065-016-0226-4. eCollection 2016. Chem Cent J. 2016. PMID: 27994641 Free PMC article.
The monomer was synthesised via the amide coupling reaction between tricarballylic acid and (triphenylmethyl) thioethylamine using two synthesis steps. The disulphide cross-linked polymers which were synthesised using the air oxidation method were completely reduced after …
The monomer was synthesised via the amide coupling reaction between tricarballylic acid and (triphenylmethyl) thioethylamine using tw …
Evidence for distinct sulfhydryl groups associated with steroid- and DNA-binding domains of rat thymus glucocorticoid receptors.
Bodwell JE, Holbrook NJ, Munck A. Bodwell JE, et al. Biochemistry. 1984 Aug 28;23(18):4237-42. doi: 10.1021/bi00313a034. Biochemistry. 1984. PMID: 6386046
The interaction of GRCs with these matrices depends on the nature of both the immobilized sulfhydryl group and the type of leaving group attached. One matrix, agarose CL-4B-diaminoethyl-succinyl-thioethylamine-2-thiopyridyl+ ++ (DSTT), binds total receptor-bound steroid. . …
The interaction of GRCs with these matrices depends on the nature of both the immobilized sulfhydryl group and the type of leaving group att …
Facile preparation and some applications of an affinity matrix with a cleavable connector arm containing a disulfide bond.
Jayabaskaran C, Davison PF, Paulus H. Jayabaskaran C, et al. Prep Biochem. 1987;17(2):121-41. doi: 10.1080/00327488708062484. Prep Biochem. 1987. PMID: 3110760
One involves the immobilization of the Fab' fragment of a monoclonal antibody against Aspergillus oryzae beta-galactosidase and the specific binding of that enzyme to the resulting immunoaffinity matrix. Another involves the immobilization of N-biotinyl-2-thioethylamine fo …
One involves the immobilization of the Fab' fragment of a monoclonal antibody against Aspergillus oryzae beta-galactosidase and the specific …